Innovative dosage forms for targeted formulations
Why are pharmaceutical pellets innovative dosage forms for targeted formulations? Pharmaceutical pellets are an advanced and versatile drug delivery form that is becoming increasingly important in the pharmaceutical industry. These spherical starter cores offer a wide range of benefits and applications, ranging from targeted drug delivery to improving patient compliance.
Pellets can have different size distributions, often ranging from 60 µm to 1,400 µm. The use of pellets allows precise control of the release kinetics of the active substance in the body, which leads to improved therapeutic effectiveness. One classifies according to inert pellets (sugar, MCC pellets) or functional pellets (acid pellets, e.g. tartaric acid pellets).
The manufacturing process of pellet formulations involves the spraying and coating techniques where the active ingredient and functional excipients are layered onto the pellet. A key advantage of pharmaceutical pellets lies in their ability to combine different active ingredients with different release profiles in a single dosage form. This is particularly useful in the treatment of diseases where a combination of multiple drugs is required or where sustained or targeted drug release is required. By precisely controlling the rate of release, pellets can help minimize unwanted side effects and maximize the effectiveness of therapy.
Another plus point is improved patient acceptance. Pellets can be filled into capsules, embedded in tablets, or even mixed into foods, making them more convenient for patients, especially those who have difficulty swallowing pills. This can increase therapy adherence and positively influence the outcome of the treatment. Also in pediatrics – medicines for newborns, babies and small children – pellet formulations offer the great advantage of adapting the dosage to the needs of these patient groups. Complex re-formulations very often become obsolete.
Advantage of pharmaceutical pellets in innovative dosage forms
Pros of Pharmaceutical Pellets
Myths about Pharmaceutical Pellets
Remember that the pros and myths can vary based on the specific drug, patient population, and therapeutic goals. It’s important to carefully consider these factors when deciding for using pharmaceutical pellets in Innovative dosage forms. With the best partnering CMDO, your drug formulation will take profit for all aspects.
Summary
Finally, pharmaceutical pellets represent a significant innovation in drug formulation. Their multiple advantages in terms of precise release, combination of active ingredients, and patient acceptance help increase drug efficacy and improve therapy outcomes. With continuous advances in pharmaceutical technology, we can’t wait to see how this formulation technique will evolve in the future.
References
[1] Pharm. Ind. 84, Nr. 12, 1440–1450 (2022)